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Ceria-NHW
- Development stage
- Preclinical
- Lead developer
- Ceria Therapeutics
- Modality
- miRNA Mimics → MicroRNA (miRNA) → Small RNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics, Nanoparticles → Drug Delivery Systems
- Administration
- Topical, Subcutaneous
01
Overview
Ceria-NHW is a therapeutic platform developed by Ceria Therapeutics for the treatment of non-healing wounds, such as diabetic foot ulcers. The drug utilizes a cerium oxide nanoparticle (CNP) delivery system conjugated with a microRNA-146a (miR-146a) mimic. This combination is designed to target the TLR4/NF-kB inflammatory pathway by suppressing the expression of Interleukin-1 receptor-associated kinase 1 (IRAK1) and TNF receptor-associated factor 6 (TRAF6). By reducing chronic inflammation and oxidative stress, Ceria-NHW aims to promote tissue repair and wound closure. It is currently in IND-enabling studies for both injectable and topical administration.
- Other names
- CNP-miR146aCNP-miR-146aCNP-miR 146aCeria-NHW
02
Targets
TRAF6IRAK1 (Interleukin-1 receptor-associated kinase 1)
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