Cernevit

Cernevit is a multivitamin formulation for intravenous administration, designed for patients who cannot receive vitamins orally. It contains 12 essential vitamins (9 water-soluble and 3 fat-soluble) but notably does not include Vitamin K[1][3][7]. ## Composition and Formulation Cernevit is presented as a lyophilized, sterile powder in an amber glass vial that requires reconstitution before administration[3]. Each vial contains: - **Water-soluble vitamins**: B1 (thiamine), B2 (riboflavin), B5 (pantothenic acid), B6 (pyridoxine), B12 (cyanocobalamin), C (ascorbic acid), biotin, niacin, and folic acid - **Fat-soluble vitamins**: A (retinol palmitate), D3 (cholecalciferol), and E (DL α-tocopherol)[2][3][7] The specific amounts per vial include: - Retinol (Vitamin A): 3500 IU - Cholecalciferol (Vitamin D3): 200-220 IU - DL α-tocopherol (Vitamin E): 10.2 mg (11.2 IU) - Ascorbic Acid (Vitamin C): 125 mg - Nicotinamide (Vitamin B3): 46 mg - Dexpanthenol: 16.15 mg (equivalent to 17.25 mg pantothenic acid) - Pyridoxine hydrochloride: 5.5 mg - And other essential vitamins[3][4][7] ## Indications and Usage Cernevit is indicated as: - A daily multivitamin maintenance dosage for adults and children aged 11 years and above receiving parenteral nutrition[1][3][7][9] - For situations where intravenous administration is required, such as surgery, extensive burns, fractures, trauma, severe infectious diseases, and comatose states[1][3] The product helps maintain the body's normal resistance and repair processes by providing necessary vitamins (except Vitamin K)[1][3]. ## Administration Cernevit is administered through: - Slow intravenous injection (at least 10 minutes) or - Infusion in a solution of 5% glucose or 0.9% sodium chloride[4][5][9] Before administration, the powder must be reconstituted with 5 ml of water for injections, 5% glucose solution, or 0.9% sodium chloride solution[4][7]. ## Special Considerations - Monitoring of liver function is recommended, particularly in patients with hepatic jaundice or cholestasis[2] - The product does not contain Vitamin K, which may need to be administered separately[1][3][7] - Clinical testing indicates some patients may not maintain adequate levels of certain vitamins when Cernevit is the sole source of vitamins for extended periods[1] - For long-term parenteral nutrition, serum vitamin levels should be monitored, and multiples of the formulation (1.5 to 3 times) may be needed if deficiencies develop[1] Cernevit is manufactured by Baxter Healthcare and is registered in more than 50 countries with over 100 million doses infused since 2013[4][8].

Brand names

Cernevit

Other names

Multivitamins for infusion