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certepetide + gemcitabine + nab-paclitaxel
- Development stage
- Unknown
- Lead developer
- Lisata Therapeutics
- Modality
- Nanoparticles → Drug Delivery Systems, Peptides, Small Molecules
- Administration
- Intravenous
01
Overview
Certepetide + gemcitabine + nab-paclitaxel is a three-drug combination regimen investigated primarily for the first-line treatment of advanced or metastatic pancreatic ductal adenocarcinoma (PDAC). **Certepetide** (also known by code names LSTA1 or CEND-1) is a novel cyclic peptide that selectively targets tumor vasculature and stroma, enhancing the uptake and penetration of co-administered anticancer drugs into tumors. *Gemcitabine* is a nucleoside analog that inhibits DNA synthesis, functioning as a cytotoxic antimetabolite. *Nab-paclitaxel* is a nanoparticle albumin-bound formulation of paclitaxel, a microtubule stabilizer, which enhances tumor delivery by exploiting albumin-mediated transport pathways. Together, the combination aims to improve outcomes over standard gemcitabine plus nab-paclitaxel by increasing intratumoral drug concentrations, leading to enhanced antitumor effect. The combination is under investigation in phase II clinical studies for metastatic PDAC.
- Other names
- certepetide + nab-paclitaxel + gemcitabine
02
Targets
MicrotubuleDCK (Deoxycytidine kinase)
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