Drug intelligence / Profile preview

Cervarix + Gardasil-9

Development stage
Phase 3
Lead developer
Merck
Modality
Vaccines & Immunotherapeutics
Administration
Intramuscular
01

Overview

Cervarix + Gardasil-9 is a combination of two prophylactic vaccines designed to protect against infection with human papillomaviruses (HPV), which are associated with the development of cervical and other anogenital cancers, as well as genital warts. Cervarix is a bivalent HPV vaccine targeting types 16 and 18, the two most common high-risk HPV types responsible for approximately 70% of cervical cancers. Gardasil-9 is a nonavalent HPV vaccine that targets nine HPV types (6, 11, 16, 18, 31, 33, 45, 52, and 58), providing broader protection against both cancer-causing and wart-causing strains. Both vaccines work by inducing neutralizing antibodies against the L1 protein of targeted HPV types using virus-like particles (VLPs) produced via recombinant DNA technology. The combination would theoretically provide overlapping and extended coverage for prevention of persistent infection with oncogenic HPVs and related diseases[1][5][6].

Other names
human papillomavirus bivalent vaccine + human papillomavirus 9-valent vaccine
02

Targets

HPV11 L1Human papillomavirus type 16 major capsid protein L1Human papillomavirus type 18 major capsid protein L1 conformational epitopesHPV31 L1Human papillomavirus type 31 native virionsHPV45 L1Human papillomavirus type 45 native virionsHPV52 L1 (Human papillomavirus type 52 major capsid protein L1)Human papillomavirus type 58 major capsid protein L1 conformational epitopesHPV6 L1 (Human papillomavirus type 6 major capsid protein L1)TLR4 (Toll-like receptor 4)HPV18 L1HPV33 L1HPV58 L1 (Human papillomavirus type 58 major capsid protein L1)

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