Clinical trials
Full profile accessFollow clinical development from study design and recruitment through results.
- Trial phase
- Status
- Readouts
Drug intelligence / Profile preview
cethrin
- Development stage
- Discontinued
- Lead developer
- Vertex
- Modality
- Recombinant Proteins and Enzymes
- Administration
- Topical
01
Overview
Cethrin is a recombinant protein therapeutic derived from the bacterial enzyme C3 transferase. It acts as an inhibitor of Rho proteins by covalently modifying and inactivating them, thereby blocking Rho-mediated axonal growth cone collapse and inhibiting neuronal apoptosis after spinal cord injury (SCI). By inhibiting Rho kinase activity at the site of injury, Cethrin promotes regeneration of cut axons and remodeling of damaged neural circuits. The drug is delivered topically during decompression surgery for acute traumatic cervical spinal cord injury. Its primary indication is for acute traumatic cervical SCI in adolescents and adults. Clinical trials have reached phase II/III development status but it does not currently have marketing authorization in any country[1][3][5][8].
- Brand names
- Cethrin
- Other names
- recombinant C3 transferase derivative
02
Targets
Rho family (Rho family GTPases)RHOA (Ras homolog gene family member A)
Beyond the preview
Go deeper on cethrin.
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Indications & development
Full profile accessExplore development by indication, patient population, and geography.
- Indications
- Development status
- Countries
Licensing & deals
Full profile accessTrace asset ownership, licensing agreements, and commercial partnerships.
- Partners
- Deal terms
- Milestones
Patents & exclusivity
Full profile accessExplore the patent landscape and regulatory exclusivity around an asset.
- Patents
- Expiration dates
- Exclusivity
Competitive landscape
Full profile accessCompare development programs by target, modality, and indication.
- Competing assets
- Targets
- Development stage
Research & analysis
Full profile accessConnect source evidence and development news to your research questions.
- Publications
- News
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on cethrin.