Drug intelligence / Profile preview

cetirizine + famotidine

Development stage
Unknown
Lead developer
UCB
Modality
Small Molecules
Administration
Oral
01

Overview

A combination therapy that blocks both histamine-1 (H1) and histamine-2 (H2) receptors. Cetirizine is an antihistamine that primarily affects the respiratory system and skin by blocking H1 receptors, while famotidine blocks gastric H2 receptors to decrease stomach acid production. This dual-histamine receptor blockade has been studied for various conditions including COVID-19, interstitial cystitis/bladder pain syndrome, and allergic conditions. The combination has shown beneficial effects in reducing inflammation and cytokine release.

Other names
Antihistamine combination therapyH1 and H2 antihistamine therapyH-1 and H2 antihistamine therapyH 1 and H2 antihistamine therapy
02

Targets

HRH2 (Histamine H2 Receptor)HRH1 (Histamine H1 Receptor)

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