Drug intelligence / Profile preview

cetrorelix + clomiphene

Development stage
Unknown
Lead developer
Merck KGaA
Modality
Small Molecules
Administration
Subcutaneous, Oral
01

Overview

A combination protocol used in assisted reproduction therapy, specifically for controlled ovarian stimulation. This approach combines cetrorelix, a GnRH antagonist that prevents premature LH surges, with clomiphene citrate, an ovulatory stimulant. The protocol typically involves starting clomiphene early in the menstrual cycle, followed by gonadotropins, with cetrorelix added when the dominant follicle reaches sufficient size. This combination is considered a "mild stimulation" or "friendly IVF" protocol aimed at reducing side effects and costs compared to traditional IVF approaches.

02

Targets

ER (Estrogen receptor)GnRHR (Gonadotropin-releasing hormone receptor)

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