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cetuximab + cisplatin + gemcitabine + vinorelbine

Development stage: Preclinical
Lead developer: Eli Lilly
Modality: Monoclonal Antibodies → Antibody-Based Therapeutics, Small Molecules
Administration: Intravenous

Overview

A combination therapy regimen consisting of cetuximab (an EGFR inhibitor monoclonal antibody), cisplatin (a platinum-based chemotherapy), gemcitabine (a nucleoside analog chemotherapy), and vinorelbine (a vinca alkaloid chemotherapy). This multi-modal approach targets cancer through different mechanisms simultaneously - inhibiting EGFR signaling pathways while disrupting cancer cell division and DNA replication.

Targets

EGFR T790M (Epidermal growth factor receptor T790M mutant)TUBB (Tubulin (alpha and beta subunits))DNA

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