Drug intelligence / Profile preview

Cetuximab nanoparticles (Abdellatif)

Development stage
Unknown
Lead developer
Ahmed A. H. Abdellatif
Modality
Monoclonal Antibodies → Antibody-Based Therapeutics, Peptides, Nanoparticles → Drug Delivery Systems
Administration
Oral
01

Overview

Cetuximab nanoparticles (Abdellatif) is an investigational oral drug delivery system designed for the targeted treatment of colorectal cancer. Developed by researcher Ahmed A. H. Abdellatif, the formulation consists of pH-sensitive polymeric nanoparticles (such as calcium alginate or PEG-based) loaded with cetuximab, a recombinant monoclonal antibody that inhibits the epidermal growth factor receptor (EGFR). To enhance specificity, the nanoparticles are decorated with octreotide, a somatostatin analogue that targets somatostatin receptors (SSTRs) frequently overexpressed in colon cancer cells. This oral delivery approach is intended to provide localized treatment to the gastrointestinal tract, potentially increasing therapeutic efficacy at the tumor site while minimizing the systemic side effects typically associated with intravenous cetuximab administration.

Other names
Octreotide-decorated cetuximab nanoparticlesOral cetuximab nanoparticlesCetuximab nanoparticles
02

Targets

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