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cetylpyridinium chloride + zinc lactate + sodium fluoride
- Development stage
- Phase 3
- Lead developer
- Colgate-Palmolive
- Modality
- Small Molecules
- Administration
- Topical
01
Overview
Cetylpyridinium chloride + zinc lactate + sodium fluoride is an alcohol-free antimicrobial mouthwash formulation developed by Colgate-Palmolive for the treatment and prevention of dental plaque and gingivitis. The combination leverages the synergistic effects of cetylpyridinium chloride (CPC), a quaternary ammonium antimicrobial that disrupts bacterial cell membranes, and zinc lactate, which enhances anti-plaque efficacy by inhibiting bacterial metabolism and volatile sulfur compound production within biofilms. Sodium fluoride is included to provide anti-caries benefits through enamel remineralization and the formation of fluorapatite. Clinical studies, including Phase 3 trials, have demonstrated that this triple-action formulation provides superior efficacy in reducing gingival inflammation and established plaque scores compared to CPC-only or fluoride-only mouthwashes over treatment periods ranging from six weeks to three months.
- Brand names
- Colgate Total Advanced Gum Health MouthwashColgate Total Active Prevention Mouthwash
- Other names
- CPC + zinc lactate + sodium fluoride mouthwashcetylpyridinium chloride + zinc lactate + sodium fluoride
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