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Drug intelligence / Profile preview
cevostamab + elranatamab
- Development stage
- Phase 1
- Lead developer
- Genentech
- Modality
- T-cell Engagers → Multispecific Antibodies → Engineered Antibody Formats → Antibody-Based Therapeutics, Bispecific Antibodies → Multispecific Antibodies → Engineered Antibody Formats → Antibody-Based Therapeutics
- Administration
- Subcutaneous
01
Overview
Cevostamab + elranatamab is an investigational combination therapy being evaluated for relapsed or refractory multiple myeloma. Cevostamab is a bispecific monoclonal antibody that targets FCRH5 (Fc receptor-homolog 5) on malignant plasma cells and CD3 on T cells, mediating T cell–directed cytotoxicity against multiple myeloma cells. Elranatamab is a bispecific antibody that targets BCMA (B cell maturation antigen) on multiple myeloma cells and CD3 on T cells, similarly engaging T cells for targeted cell lysis. This combination is designed to achieve deeper tumor responses by simultaneously targeting two different antigens on myeloma cells and activating endogenous T cell responses[1][4][5].
- Other names
- cevostamab + elranatamab
02
Targets
BCMA (B-cell maturation antigen)CD3 (T-cell surface glycoprotein CD3)FCRL5 (Fc receptor-like protein 5)
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