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CfaEp3
- Development stage
- Preclinical
- Lead developer
- Naval Medical Research SOUTH
- Modality
- Vaccines & Immunotherapeutics, Recombinant Proteins and Enzymes
- Administration
- Intradermal
01
Overview
CfaEp3 (CfaEB-CsuA2-CsfA) is a recombinant fusion protein vaccine candidate designed to prevent diarrhea caused by Enterotoxigenic Escherichia coli (ETEC). Developed by Naval Medical Research SOUTH (formerly NAMRU-6), the vaccine is based on the CFA/I adhesin-pilin fusion (CfaEB) fused to the pilins of colonization factors CS14 (CsuA2) and CS4 (CsfA). It is designed to generate broad cross-protection against members of ETEC subclass 5a fimbriae. In preclinical studies using a non-human primate challenge model, CfaEp3 administered intradermally with a dmLT adjuvant demonstrated protective efficacy against CS14+ ETEC challenge.
- Other names
- CfaEB-CsuA2-CsfACfaEB-CsuA-2-CsfACfaEB-CsuA 2-CsfA
02
Targets
CfaB (Colonization factor antigen I major fimbrial subunit)CfaE (Colonization factor antigen I minor subunit CfaE)CsuA2 (Enterotoxigenic Escherichia coli CS14 fimbrial subunit CsuA2)
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