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CFH protein-loaded ice microneedles
- Development stage
- Unknown
- Lead developer
- West China Hospital of Sichuan University
- Modality
- Recombinant Proteins and Enzymes
- Administration
- Intradermal
01
Overview
CFH protein-loaded ice microneedles is an investigational drug-device combination consisting of a recombinant human Complement Factor H (CFH) protein fragment (residues 860-1231) encapsulated within a meltable ice microneedle platform. Developed by West China Hospital of Sichuan University, it is designed for intradermal delivery to prevent radiation-induced skin fibrosis (RISF) in patients with head and neck squamous cell carcinoma (HNSCC) receiving postoperative adjuvant radiotherapy. Complement Factor H is a critical regulatory protein of the alternative complement pathway; by delivering it directly into the skin, the therapy aims to inhibit complement-mediated inflammatory and fibrotic signaling cascades triggered by radiotherapy. The ice microneedle technology allows for the stable encapsulation of the protein in a frozen state and minimally invasive delivery as the needles melt upon contact with skin temperature, releasing the active biologic fragment into the dermal layer.
- Other names
- complement factor H ice microneedlesCFH ice microneedle patch
02
Targets
GAGs (Glycosaminoglycans)Alternative pathway C3 and C5 convertase complexes
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