cFLFLF

cFLFLF is a synthetic peptide consisting of N-cinnamoyl-phenylalanine-(D)-leucine-phenylalanine-(D)-leucine-phenylalanine, designed as a high-affinity antagonist for the **formyl peptide receptor (FPR1)** on neutrophils[1][3]. Its mechanism of action involves antagonizing FPR1, providing selective binding to neutrophils without eliciting chemotactic responses, thus avoiding unwanted neutropenia or activation[1]. It has been applied primarily as a molecular imaging agent (when radiolabeled, e.g., with ^64Cu) for detecting sites of acute neutrophilic inflammation, demonstrated in both animal models (mouse, macaque) via PET/CT imaging[1][2][3]. cFLFLF and its pegylated derivatives are notable for their use in research settings to probe inflammatory disease processes and potentially facilitate studies of anti-inflammatory therapies[1][2].

Other names

N-cinnamoyl-F-(D)L-F-(D)L-FFLFLF