CFM-4.16

CFM-4.16 is a novel small molecule analog of CFM-4 that acts as a functional mimetic of Cell Cycle and Apoptosis Regulatory Protein 1 (CARP-1/CCAR1). CARP-1 is a peri-nuclear phosphoprotein essential for apoptosis signaling induced by various chemotherapeutic agents. CFM-4.16 binds directly to CARP-1, stimulating its expression and triggering ROS-dependent apoptosis, which involves the activation of stress-activated protein kinases (SAPKs) like p38 and JNK, and the cleavage of caspases. Additionally, CFM-4.16 has been shown to inhibit the activation and expression of oncogenic drivers such as c-Met, Akt, and STAT3. It is particularly effective against drug-resistant cancer cells, including cisplatin-resistant and doxorubicin-resistant triple-negative breast cancer (TNBC), erlotinib-resistant non-small cell lung cancer (NSCLC), and everolimus-resistant renal cell carcinoma (RCC). Experimental formulations, including nanolipid and micellar delivery systems, have been developed to enhance its solubility and tumor-specific targeting.

Other names

CARP-1 functional mimetic 4.16CARP1 functional mimetic 4.16CARP 1 functional mimetic 4.16