CFTR inhibitor-172

CFTR inhibitor-172 (CFTRinh-172) is a small-molecule thiazolidinone that acts as a potent, selective, and voltage-independent inhibitor of the cystic fibrosis transmembrane conductance regulator (CFTR) chloride channel. Originally identified via high-throughput screening in the laboratory of Alan Verkman at the University of California, San Francisco (UCSF), the compound binds inside the channel pore near transmembrane helix 8, stabilizing a closed, non-conductive conformation. While it has been investigated preclinically as an anti-secretory agent for secretory diarrhea (such as cholera toxin-induced intestinal fluid secretion) and autosomal dominant polycystic kidney disease, CFTR inhibitor-172 is primarily utilized as a research-use-only laboratory tool to study CFTR function and gating mechanisms.

Other names

3-[(3-trifluoromethyl)phenyl]-5-[(4-carboxyphenyl)methylene]-2-thioxo-4-thiazolidinone4-[[4-oxo-2-thioxo-3-[3-(trifluoromethyl)phenyl]-5-thiazolidinylidene]methyl]benzoic acidCFTR(inh)-172Cystic Fibrosis Transmembrane Conductance Regulator Inhibitor 172