Drug intelligence / Profile preview

CG003301

Development stage
Preclinical
Lead developer
Cullgen
Modality
PROTACs (E3 ligase recruitment) → Targeted Protein Degraders (TPDs) → Small Molecules, Bivalent/Multivalent Binders → Multivalent & Scaffold-Based Small Molecules → Small Molecules
01

Overview

CG003301 is an undisclosed targeted protein degrader (TPD) being developed by Cullgen for the treatment of various oncology indications. Developed using Cullgen's proprietary uSMITE™ (ubiquitin-mediated small molecule induced target elimination) platform, the drug is designed to selectively degrade a specific disease-causing protein by hijacking the body's ubiquitin-proteasome system. While the specific molecular target remains undisclosed, the program represents part of Cullgen's broader pipeline of small molecule degraders aimed at addressing high-value targets in cancer that may be difficult to inhibit with traditional small molecule inhibitors.

02

Targets

GSPT1 (G1 to S phase transition 1)

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