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CG428
- Development stage
- Unknown
- Lead developer
- Legacy Healthcare
- Modality
- Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules
- Administration
- Topical
01
Overview
**CG428** is an investigational topical proprietary botanical lotion developed by Legacy Healthcare for chemotherapy-induced alopecia, including persistent or permanent chemotherapy-induced alopecia in cancer survivors. It contains a four-botanical blend of **Allium cepa** onion, **Citrus limon** citrus, **Theobroma cacao** cocoa, and **Paullinia cupana** guarana. The proposed activity is local modulation of hair-follicle apoptosis and scalp inflammation, with the aim of restoring normal hair cycling and promoting hair regrowth. In a small randomized, double-blind pilot study in breast cancer survivors with permanent chemotherapy-induced alopecia, CG428 was generally tolerated and showed non-significant trends toward improved hair density and patient-reported improvement versus placebo. ([cancer.gov](https://www.cancer.gov/publications/dictionaries/cancer-drug/def/botanical-lotion-cg428))
- Brand names
- CebretonCellium
- Other names
- botanical lotion CG428
02
Targets
CRBN (Cereblon)NTRK1 (Tropomyosin-related receptor kinase A)NTRK2 (Tropomyosin-related kinase receptor type B)NTRK3 (Tropomyosin receptor kinase C)PDE (Phosphodiesterase family)ADOR (Adenosine receptors)
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