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CGC-738

Development stage: Phase 1
Lead developer: Cure Genetics
Modality: CAR-T Cells → Engineered T Cells → Adoptive Cell Transfer → Cell Therapies
Administration: Intravenous

Overview

CGC-738 is a CD70-targeted chimeric antigen receptor natural killer T (CAR-NKT) cell therapy developed by Suzhou Cure Genetics for the treatment of advanced malignant solid tumors, including advanced clear cell renal cell carcinoma. The therapy involves genetically engineering NKT cells to express a CAR that targets the CD70 antigen, which is overexpressed in certain tumor types. By targeting CD70, these engineered cells are designed to recognize and kill cancer cells expressing this antigen. As of 2025, CGC-738 is in phase 1 clinical trials for solid tumors and metastatic renal cell carcinoma[1][2][3][4][5].

Other names: CD70-targeted CAR-NKT CellsCD-70-targeted CAR-NKT CellsCD 70-targeted CAR-NKT CellsCD70 CAR-NKT cellsCD-70 CAR-NKT cellsCD 70 CAR-NKT cells

Targets

CD70 (Cluster of Differentiation 70)

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