CGRP8-37

**CGRP8-37** is a synthetic peptide fragment corresponding to residues 8-37 of the human calcitonin gene-related peptide (CGRP). It acts as a **selective antagonist of the calcitonin gene-related peptide (CGRP) receptor**, specifically blocking the vasodilatory and pro-nociceptive effects induced by CGRP. CGRP8-37 has been widely used in preclinical research to investigate the physiological and pathological roles of CGRP signaling, including roles in pain, vasodilation, migraine, and edema. In animal studies, CGRP8-37 effectively blocks CGRP-induced increases in blood flow and edema, with selectivity for the alpha-CGRP isoform. It is not a therapeutic drug but a research reagent targeting the CGRP receptor pathway in models of chronic pain, migraine, cardiovascular disease, and other conditions where CGRP is implicated[1][2][3][6][11][14].

Other names

Calcitonin Gene-Related Peptide 8-37CGRP (8-37)human CGRP8-37rat CGRP8-37