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CH-10D7ICG
- Development stage
- Preclinical
- Lead developer
- The University of Queensland
- Modality
- Small Molecules, Cytotoxic ADCs → Antibody-Drug Conjugates (ADCs) → Antibody Conjugates → Antibody-Based Therapeutics
- Administration
- Intravenous
01
Overview
CH-10D7ICG is a **fluorescent probe** created by chemically conjugating the near-infrared dye **indocyanine green (ICG)** to the monoclonal antibody **10D7**, which specifically targets the CUB-domain-containing protein 1 (CDCP1), a receptor overexpressed on ovarian cancer cells. This agent is developed to enable **tumor-selective fluorescence imaging**, enhancing the visualization of ovarian cancer lesions during surgery. Preclinical studies have shown intravenous administration of CH-10D7ICG allows preferential accumulation in ovarian cancer xenografts, supporting its potential use in **fluorescence-guided surgery for ovarian cancer**[1].
- Other names
- 10D7-ICG
02
Targets
CDCP1 (CUB domain-containing protein 1)
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