ch-siZNF711

ch-siZNF711 is an experimental antagonistic chimeric small interfering RNA (siRNA) designed to target and silence the expression of Zinc Finger Protein 711 (ZNF711). Research indicates that ZNF711 is significantly overexpressed in enzalutamide-resistant prostate cancer, where it acts as a dual regulator of the androgen receptor (AR) signaling pathway. Mechanistically, ZNF711 binds directly to the AR promoter to transcriptionally upregulate its expression and forms a complex with BMI1 and AR to enhance signaling through epigenetic demethylation of target gene promoters (e.g., KLK3, TMPRSS2). By knocking down ZNF711, ch-siZNF711 reduces AR expression and chromatin occupancy, thereby restoring sensitivity to enzalutamide in castration-resistant prostate cancer models. In vivo studies have demonstrated its potential as a therapeutic strategy to overcome acquired resistance to AR inhibitors.

Other names

ZNF711 chimeric siRNAZNF-711 chimeric siRNAZNF 711 chimeric siRNAantagonistic chimeric siRNA targeting ZNF711