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ChAdOx1 LassaJ
- Development stage
- Unknown
- Lead developer
- University of Oxford
- Modality
- Vaccines & Immunotherapeutics
- Administration
- Intramuscular
01
Overview
ChAdOx1 LassaJ is an investigational viral vector vaccine developed by the University of Oxford's Oxford Vaccine Group and the Pandemic Sciences Institute to prevent Lassa fever. Utilizing the non-replicating chimpanzee adenovirus platform (ChAdOx1), the vaccine encodes the Lassa virus glycoprotein complex (GPC) to stimulate both humoral and cellular immune responses. Lassa fever is a viral hemorrhagic illness endemic to West Africa, primarily transmitted via rodents. The vaccine is currently being evaluated in Phase 1 clinical trials (e.g., VITAL01) to assess safety and immunogenicity in healthy adults.
- Other names
- ChAdOx1-Lassa-GPCChAdOx-1-Lassa-GPCChAdOx 1-Lassa-GPCChAdOx1 Lassa vaccineChAdOx-1 Lassa vaccineChAdOx 1 Lassa vaccine
02
Targets
GPC (Lassa virus glycoprotein complex)
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