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Chai-Gui Jieyu Qufa Granules
- Development stage
- Preclinical
- Lead developer
- Cancer Institute and Hospital, Chinese Academy of Medical Sciences
- Administration
- Oral
01
Overview
Chai-Gui Jieyu Qufa Granules (also known as Chaigui Jieyu Qufa Decoction) is a compound traditional Chinese herbal granule preparation developed by the Cancer Institute and Hospital, Chinese Academy of Medical Sciences. It is formulated based on traditional Chinese medicine principles to address the syndrome of liver depression and spleen deficiency. The preparation contains several herbal ingredients, including Bupleurum chinense (Chaihu), Cinnamomum cassia (Guizhi), Scutellaria baicalensis (Huangqin), Pinellia ternata (Banxia), Atractylodes macrocephala (Baizhu), Paeonia lactiflora (Baishao), Codonopsis pilosula (Dangsheng), Zingiber officinale (Ganjiang), Citrus aurantium (Zhishi), Carapax Trionycis (Biejia), Agrimonia pilosa (Xianhecao), Ficus hirta (Wuzhimaotao), Rhodiola rosea (Hongjingtian), and Smilax china (Baqia). Chai-Gui Jieyu Qufa Granules is being evaluated in clinical trials for the treatment of cancer-related fatigue (CRF) in patients with driver gene-negative lung adenocarcinoma undergoing first-line chemoimmunotherapy.
- Other names
- CGJYQFChai-Gui Jieyu Qufa DecoctionChaigui Jieyu Qufa DecoctionChaigui Jieyu Qufa GranulesChaiyu Jieyu Qufa Decoction柴桂解郁祛乏方柴桂解郁祛乏颗粒
02
Targets
ADK (Adenosine kinase)AMPD (AMP deaminase)AMPD3IL10 (Interleukin-10)IL1B (Interleukin-1 beta)IL-2 (Interleukin 2)IL-6 (Interleukin 6)NT5C2 (5'-nucleotidase, cytosolic II)NT5E (Cluster of Differentiation 73)ODC1 (Ornithine decarboxylase)PDE10A (Phosphodiesterase 10A)PDE11A (Phosphodiesterase 11A)PDE2 (Phosphodiesterase 2)PDE3A (Phosphodiesterase 3A)
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