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Chai Gui Long Mu Tang

Development stage: Preclinical
Lead developer: Longhua Hospital Shanghai University of Traditional Chinese Medicine
Administration: Oral

Overview

Chai Gui Long Mu Tang is a Traditional Chinese Medicine (TCM) herbal formula primarily composed of Bupleurum (Chai Hu), Cinnamon twig (Gui Zhi), Fossil bone (Long Gu), and Oyster shell (Mu Li). It is currently being investigated by Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine for its potential to mitigate trastuzumab-induced cardiotoxicity in patients with breast cancer. The formula is a variation of the classic 'Chai Hu Jia Long Gu Mu Li Tang' and is traditionally used to soothe the liver, clear heat, and anchor the spirit to treat symptoms like palpitations and anxiety. In the context of oncology, it is hypothesized to provide cardioprotection by modulating oxidative stress and inflammatory pathways associated with HER2-targeted therapy.

Other names: Chaihu Guizhi Longgu Muli TangChai Hu Jia Long Gu Mu Li TangModified Chai Gui Long Mu TangJia Jian Chai Gui Long Mu Tang

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