Drug intelligence / Profile preview

chai hu jia long gu mu li tang

Development stage
Phase 4
Administration
Oral
01

Overview

Chai Hu Jia Long Gu Mu Li Tang (柴胡加龙骨牡蛎汤) is a classic multi-herb formula from traditional Chinese medicine (TCM), first described in the Shang Han Lun by Zhang Zhong-Jing. It is a modification of Minor Bupleurum Decoction (Xiao Chai Hu Tang), with the addition of dragon bone (Long Gu) and oyster shell (Mu Li) to enhance its calming and grounding effects. The formula is traditionally used to harmonize the Shaoyang stage of disease, calm agitation or restlessness, anchor "floating Yang," and support emotional balance. Its main indications include palpitations, insomnia, irritability, emotional disorders such as anxiety or agitation, stress-induced hypertension, trauma recovery symptoms like nervous tension or dizziness, digestive disturbances including constipation due to emotional distress or internal heat patterns[1][2][3][4][5]. Mechanistically in TCM terms it calms the spirit by anchoring Yang and harmonizing Qi flow; from a biomedical perspective it may exert neuroprotective effects and modulate neurotransmitter activity[1]. The typical ingredients are bupleurum root (Chai Hu), pinellia rhizome (Ban Xia), poria mushroom (Fu Ling), cinnamon twig (Gui Zhi), Chinese skullcap root (Huang Qin), jujube fruit (Da Zao), ginger rhizome (Sheng Jiang), ginseng root (Ren Shen/Bai Shen), dragon bone mineral fossilized bone material rich in calcium compounds(Long Gu), oyster shell mineral(Mu Li) and rhubarb root/rhizome(Da Huang)[3][6].

Brand names
Calm Dragon FormulaBupleurum plus Dragon Bone and Oyster Shell DecoctionBupleurum & D.B. Combination
Other names
柴胡加龙骨牡蛎汤Chai-Hu-Jia-Long-Gu-Mu-Li-TangChai Hu Jia Long Gu Mu Li Tang柴胡加龍骨牡蠣湯
02

Targets

AKT1 (Proto-oncogene serine/threonine-protein kinase Akt1)MAPK3 (Mitogen-activated protein kinase 1)PIK3R1 (Phosphatidylinositol 4-phosphate 3-kinase regulatory subunit alpha)

Beyond the preview

Go deeper on chai hu jia long gu mu li tang.

Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.

Clinical trials

Follow clinical development from study design and recruitment through results.

  • Trial phase
  • Status
  • Readouts

Indications & development

Explore development by indication, patient population, and geography.

  • Indications
  • Development status
  • Countries

Licensing & deals

Trace asset ownership, licensing agreements, and commercial partnerships.

  • Partners
  • Deal terms
  • Milestones

Patents & exclusivity

Explore the patent landscape and regulatory exclusivity around an asset.

  • Patents
  • Expiration dates
  • Exclusivity

Competitive landscape

Compare development programs by target, modality, and indication.

  • Competing assets
  • Targets
  • Development stage

Research & analysis

Connect source evidence and development news to your research questions.

  • Publications
  • News
  • Analysis

Bring the full picture into focus.

See how Gosset can support your research on chai hu jia long gu mu li tang.

Gosset Free

Get started with Gosset.

Enter your corporate email.

Work email preferred.

Book a call