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Chaigui Granules
- Development stage
- Phase 2
- Lead developer
- Shanxi University
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
Chaigui Granules is a Traditional Chinese Medicine (TCM) formulation developed by the Modern Research Center for Traditional Chinese Medicine at Shanxi University for the treatment of mild to moderate depression. The drug is a refined granule composed primarily of extracts from *Bupleurum chinense* (Chaihu) and *Angelica sinensis* (Danggui), targeting the liver-qi stagnation and blood deficiency patterns in TCM theory. Pharmacological studies indicate that Chaigui Granules exerts its antidepressant effects through multiple pathways, including the modulation of the hypothalamic-pituitary-adrenal (HPA) axis, enhancement of brain-derived neurotrophic factor (BDNF) expression in the hippocampus, and regulation of monoamine neurotransmitters such as serotonin, dopamine, and norepinephrine. It has progressed into Phase III clinical development in China, demonstrating a favorable safety profile and significant efficacy in reducing depressive symptoms compared to placebo.
- Brand names
- Chaigui Granules
- Other names
- Chai-Gui GranulesChaihu-Danggui Granules
02
Targets
5-HT (Serotonin receptors)BDNF (Brain-derived neurotrophic factor)GR (Glucocorticoid receptor)NET (Norepinephrine Transporter)
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