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Chaihu Anxin Capsule
- Development stage
- Unknown
- Lead developer
- The First Hospital of Hebei Medical University
- Modality
- Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules
- Administration
- Oral
01
Overview
Chaihu Anxin Capsule is a Traditional Chinese Medicine (TCM) botanical formulation developed by The First Hospital of Hebei Medical University for the treatment of mild to moderate depressive disorder. It is currently undergoing clinical evaluation in China to determine its efficacy and safety in patients experiencing a single episode of depression. The therapeutic approach involves investigating the drug's impact on the gut microbiome, suggesting a mechanism of action involving the gut-brain axis. The name 'Chaihu' refers to *Bupleurum*, a staple herb in TCM used for its purported ability to relieve emotional stagnation and regulate the liver-qi, which is traditionally linked to mood regulation.
- Brand names
- Chaihu Anxin Capsule
- Other names
- Chaihu Anxin Capsule
02
Targets
JUN (Transcription factor Jun)STAT3 (Signal Transducer and Activator of Transcription 3)AKT1 (Proto-oncogene serine/threonine-protein kinase Akt1)TP53 (Cellular Tumor Antigen p53 R175H)IL-6 (Interleukin 6)
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