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chaiqin pediatric antipyretic suppository
- Development stage
- Phase 2
- Lead developer
- Anhui Institute of Pharmaceutical Research
- Modality
- Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules
- Administration
- Rectal
01
Overview
Chaiqin pediatric antipyretic suppository is a Traditional Chinese Medicine (TCM) formulation developed for the treatment of fever in children, particularly those suffering from acute upper respiratory infections characterized by the "wind-heat" pattern. The drug is developed by the Anhui Institute of Pharmaceutical Research. Its primary active components are derived from *Radix Bupleuri* (Chaihu) and *Radix Scutellariae* (Huangqin), which are traditionally used in TCM for their antipyretic, anti-inflammatory, and detoxifying properties. Administered rectally as a suppository, it offers a non-oral delivery route suitable for pediatric patients who may experience difficulty with oral medications during illness.
- Other names
- Chaiqin Xiaoer Tuire ShuanChaiqin pediatric antipyretic suppository
02
Targets
MYD88 (Myeloid differentiation primary response protein MyD88)NLRP3 (Nod-like receptor family pyrin domain-containing protein 3)GRIN2B (N-methyl-D-aspartate Receptor Subunit Combination: NR1a/NR2B)PI3K (Phosphoinositide-3-kinase regulatory subunit 6)TLR4 (Toll-like receptor 4)
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