chamaejasmine

**Chamaejasmine** is a naturally occurring biflavonoid mainly found in plants such as Stellera chamaejasme and Wikstroemia dolichantha. It has shown multiple pharmacological activities, including **anti-inflammatory** effects (notably in topical models of atopic dermatitis), and **antiproliferative/anticancer** effects in various cancer cell lines (such as osteosarcoma, cervical, lung, liver, and larynx cancer). For atopic dermatitis, chamaejasmine restores skin barrier function, reduces serum IgE and interleukin-4 levels, and reduces itching, dryness, erythema, and edema when applied topically. Its anti-cancer mechanisms include inducing apoptosis through both intrinsic (mitochondrial) and extrinsic (death receptor) pathways, involving altered Bcl-2/Bax ratios, cytochrome c release, and caspase 3 and caspase 9 activation. It also suppresses PI3K/Akt signaling in certain cancers[1][4][6].

Other names

chamaejasmine69618-96-82,2',3,3'-Tetrahydro-5,5',7,7'-tetrahydroxy-2,2'-bis(4-hydroxyphenyl)-3,3'-bi[4H-1-benzopyran]-4,4'-dione(2R,3S)-3-[(2R,3S)-5,7-dihydroxy-2-(4-hydroxyphenyl)-4-oxo-2,3-dihydrochromen-3-yl]-5,7-dihydroxy-2-(4-hydroxyphenyl)-2,3-dihydrochromen-4-one