Drug intelligence / Profile preview

chamomile

Development stage
Phase 3
Lead developer
University of Pennsylvania
Administration
Oral, Topical, Rectal
01

Overview

Chamomile is a **botanical drug/herbal medicine** derived from the flower heads of *Matricaria chamomilla*/*Chamomilla recutita* and used in multiple oral and topical formulations. Its pharmacology is attributed to a mixture of plant secondary metabolites, especially flavonoids and terpenoids such as apigenin, bisabolol, and chamazulene-containing constituents, which are associated with anti-inflammatory, soothing, spasmolytic, and anxiolytic effects. In the provided public sources, chamomile appears as oral extract capsules studied for chemotherapy-induced nausea and vomiting, topical gel or liposomal gel studied for prevention or management of radiation dermatitis in breast and head and neck cancer, and oral therapy studied clinically for generalized anxiety disorder. Because \"chamomile\" names a plant-derived preparation rather than one single chemically defined active substance, product composition can vary substantially by species, extraction method, concentration, and dosage form.

Brand names
KamillanKamillinKamillin Extern RobugenKamillin Konzentrat RobugenKamillosan
Other names
Matricaria chamomillaChamomilla recutitaMatricaria recutitaGerman chamomile
02

Targets

PTGS2 (Prostaglandin-Endoperoxide Synthase 2)Cyp (Cyclophilin family)GABAA (Gamma-aminobutyric acid receptor)TACR1 (Neurokinin‑1 Receptor)NFE2L2 (Nuclear factor (erythroid-derived 2)-like 2)

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