Drug intelligence / Profile preview

chamomile oil

Development stage
Phase 4
Modality
Small Molecules
Administration
Oral, Topical, Inhalation, Intranasal
01

Overview

Chamomile oil is an essential oil derived from the flowers of chamomile plants, primarily *Matricaria chamomilla* (German chamomile) and *Chamaemelum nobile* (Roman chamomile). It contains active compounds such as flavonoids, terpenoids (including alpha-bisabolol), coumarins, and apigenin. Chamomile oil exhibits a range of pharmacological effects, including anti-inflammatory, analgesic, antispasmodic, anxiolytic, mild sedative, antioxidant, antimicrobial, hepatoprotective, and antihistamine activities[6][4][2][1]. The active constituents modulate inflammation (e.g., by inhibiting cyclooxygenase and lipoxygenase pathways), relax smooth muscle, and act as mild central nervous system depressants, which account for its effects in reducing anxiety, sleep problems, skin irritation, arthritic pain, digestive upset, and menstrual discomfort[6][2][3][4][5][1]. Chamomile oil is used topically, orally, and by inhalation for eczema, wound healing, allergic rhinitis, generalized anxiety disorder, depression, sleep aid, digestive conditions (indigestion, nausea, diarrhea), musculoskeletal pain, and respiratory issues. It is not an approved pharmaceutical drug but is a widely used herbal remedy with certain clinical research support[6][4][2][3][1].

Other names
chamomile essential oilRoman chamomile oilGerman chamomile oil
02

Targets

PTGS2 (Prostaglandin-Endoperoxide Synthase 2)GABRR (GABA-A receptor subunit rho)H (Histamine receptors)15-LOX (Lysyl Oxidase)

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