Drug intelligence / Profile preview

chamomilla recutita topical formulation

Development stage
Unknown
Lead developer
University of Brasília
Modality
Small Molecules
Administration
Topical
01

Overview

Chamomilla recutita topical formulation refers to a series of botanical preparations, including a 8.35% gel and a 2.5% infusion, developed by the University of Brasilia for the management of radiodermatitis. The drug utilizes the therapeutic properties of German chamomile, which contains active compounds like alpha-bisabolol and chamazulene known for their potent anti-inflammatory, antioxidant, and wound-healing effects. By inhibiting the inflammatory cascade and neutralizing reactive oxygen species generated during radiotherapy, these formulations aim to prevent and treat skin damage in patients undergoing treatment for breast or head and neck cancers. The development program includes a Phase 3 clinical trial (NCT02251392) comparing the efficacy of these chamomile-based interventions against standard urea-based creams.

Other names
Chamomilla recutita gelChamomilla recutita infusionGerman chamomile gelChamomila recutita GelChamomila recutita Infuse
02

Targets

PTGS2 (Prostaglandin-Endoperoxide Synthase 2)

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