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Changan Granules
- Development stage
- Phase 2
- Lead developer
- Shanghai Traditional Chinese Medicine Dayuanchuang Technology
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
Changan Granules is a Traditional Chinese Medicine (TCM) formulation developed by Shanghai Traditional Chinese Medicine University Yuanchuang Technology Co., Ltd. specifically for the treatment of diarrhea-predominant irritable bowel syndrome (IBS-D). The formula is derived from the classical TCM prescription "Tongxie Yaofang," which has been modified to better address the pathophysiology of IBS-D, including abdominal pain and frequent loose stools. Its mechanism of action is multi-targeted, involving the reduction of visceral hypersensitivity, modulation of the brain-gut axis, and regulation of intestinal permeability and gut microbiota. Clinical studies have indicated that Changan Granules can significantly improve the IBS-D Symptom Severity Score (IBS-SSS) and patient quality of life by inhibiting mast cell activation and regulating serotonin (5-HT) levels in the colonic mucosa.
- Brand names
- Changan Granules
- Other names
- Changan KeliChang-An-Ke-LiChang'an Granule
02
Targets
5-HT (Serotonin receptors)
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