Changchun Genescience Pharma GHSR-1a compound 4b

Changchun Genescience Pharma GHSR-1a compound 4b: sourced facts only. name: "Starting from capromorelin, we designed, synthesized, and characterized a novel orally active GHSR-1a agonist, compound 4b (hGHSR-1a EC50 = 0.49 nM), which effectively stimulates endogenous GH release in rats at oral doses as low as 0.1 mg/kg─100-fold more potent than ibutamoren (10 mg/kg)." [PMID:40091212]; target: "Starting from capromorelin, we designed, synthesized, and characterized a novel orally active GHSR-1a agonist, compound 4b (hGHSR-1a EC50 = 0.49 nM), which effectively stimulates endogenous GH release in rats at oral doses as low as 0.1 mg/kg─100-fold more potent than ibutamoren (10 mg/kg)." [PMID:40091212]; developer: "Changchun Genescience Pharma, 88 Hongmei Road, Xuhui District, Shanghai 200233, China." [PMID:40091212]; stage: "Notably, 10 day oral administration of 4b increased body weight and length in 4-week-old rats." [PMID:40091212]