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changkang granules
- Development stage
- Phase 3
- Lead developer
- Tasly Pharmaceutical
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
Changkang Granules is a traditional Chinese medicine (TCM) formulation developed for the treatment of diarrhea-predominant irritable bowel syndrome (IBS-D). It is currently in Phase 3 clinical development. The drug has been evaluated in multicenter, randomized, double-blind, placebo-controlled trials to assess its efficacy and safety for IBS-D. The mechanism of action is being explored through metabolomics and systems biology approaches to clarify how it affects endogenous substances and potential clinical biomarkers in patients with IBS-D. Changkang Granules was initially developed by Tasly Pharmaceutical Group.
- Brand names
- changkang granules
- Other names
- none
02
Targets
BDNF (Brain-derived neurotrophic factor)CGRP (Calcitonin gene-related peptide)HTR1A (Serotonin receptor 1A (5-hydroxytryptamine receptor 1A))SP (Substance P)CREB1 (Cyclic AMP response element-binding protein 1)
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