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Changrui Guanchang San
- Development stage
- Unknown
- Lead developer
- Shanxi Zhendong Pharmaceutical
- Modality
- Small Molecules
- Administration
- Rectal
01
Overview
Changrui Guanchang San is a Traditional Chinese Medicine (TCM) formulation developed by Shanxi Zhendong Pharmaceutical for the treatment of chronic radiation proctitis. Administered as a retention enema, the drug is designed to alleviate symptoms such as rectal bleeding, pain, and tenesmus by promoting mucosal repair and reducing local inflammation. The formulation typically contains a mixture of herbal extracts, including *Sanguisorba officinalis* and *Bletilla striata*, which provide hemostatic and wound-healing properties. It has undergone Phase III clinical trials in China, demonstrating efficacy in improving the clinical symptoms and endoscopic appearance of the rectal mucosa in patients suffering from radiation-induced injury following pelvic malignancy treatment.
- Brand names
- Changrui
- Other names
- Changrui Enema Powder
02
Targets
TNFA (Tumor necrosis factor alpha (soluble))IL-6 (Interleukin 6)
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