Drug intelligence / Profile preview

Changtong Oral Liquid

Development stage
Unknown
Lead developer
Nanfang Hospital, Southern Medical University
Modality
Small Molecules
Administration
Oral, Rectal
01

Overview

Changtong Oral Liquid is a Traditional Chinese Medicine (TCM) formulation developed by the Nanfang Hospital of Southern Medical University (formerly the First Military Medical University). It is primarily utilized in the postoperative management of patients undergoing abdominal surgery, particularly for rectal malignant tumors, to prevent the formation of postoperative peritoneal adhesions and intestinal obstruction. The preparation is based on classical purgative formulas and typically contains herbal ingredients such as *Rheum palmatum*, *Magnolia officinalis*, *Aurantii Fructus Immaturus*, and *Mirabilite*. Its therapeutic effects are attributed to the stimulation of gastrointestinal motility and the inhibition of inflammatory pathways. Specifically, it has been shown to downregulate the expression of pro-fibrotic and pro-inflammatory factors such as TGF-beta1, TNF-alpha, and IL-6, thereby reducing the fibroblastic activity that leads to adhesions. It is commonly administered orally or via a gastric tube in the early postoperative phase to facilitate the recovery of bowel function.

Brand names
Changtong Oral Liquid
Other names
Changtong KoufuyeChang-Tong Oral Liquid
02

Targets

TGFB1 (Transforming growth factor Beta-1 proprotein)

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