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Drug intelligence / Profile preview
charantin
- Development stage
- Preclinical
- Modality
- Small Molecules
- Administration
- Oral, Intravenous, Intranasal
01
Overview
**Charantin** is a plant-derived steroidal glycoside preparation isolated principally from *Momordica charantia* (bitter melon). The commonly used chemical definition is a naturally occurring mixture of beta-sitosteryl glucoside and stigmasteryl glucoside. It has been investigated preclinically for metabolic effects, including antihyperglycemic and lipid-lowering activity. In a high-lipid-diet rat model, charantin reduced circulating cholesterol, triglycerides, LDL, and VLDL while increasing HDL; reported mechanistic findings included reduced HMGCR, PCSK9, and APOB expression and increased LDLR and PPAR-alpha expression. Charantin is not an established approved pharmaceutical product for hyperlipidemia or diabetes.
- Other names
- charantin
02
Targets
AR (Adrenergic receptors)INSR (Insulin receptor)IL1B (Interleukin-1 beta)IL12 (Interleukin-12)Sucrase-IsomaltaseGANAB (Alpha-glucosidase II)AMY (Pancreatic alpha-amylase)HMGCR (3-hydroxy-3-methylglutaryl-coenzyme A reductase)PPARA (Peroxisome proliferator-activated receptor alpha)PCSK9 (Proprotein convertase subtilisin/kexin type 9)
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