Drug intelligence / Profile preview

Chazhu Xiaozhi decoction

Development stage
Phase 2
Lead developer
Chongqing City Hospital of Traditional Chinese Medicine
Administration
Oral
01

Overview

Chazhu Xiaozhi decoction is a traditional Chinese medicine (TCM) herbal formulation under clinical investigation for the treatment of non-alcoholic fatty liver disease (NAFLD). It is administered as a daily oral decoction and evaluated for its ability to improve hepatic steatosis and overall liver health in adults with NAFLD, particularly those diagnosed with Spleen Deficiency and Damp-Heat Syndrome according to TCM criteria. The mechanism of action is not fully elucidated but, like other TCM formulas used for similar indications, it likely acts through multi-target modulation of inflammation, lipid metabolism, and possibly gut-liver axis pathways. Chazhu Xiaozhi decoction is compared against placebo in randomized controlled trials to assess efficacy and safety[1].

Other names
Chazhu Xiaozhi formula
02

Targets

IL-6 (Interleukin 6)VEGFA (Vascular endothelial growth factor A)MMP9 (Matrix metalloproteinase-9)RELA (Nuclear Factor Kappa B Subunit p65)

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