chemotherapy + vitamin D2

The intervention referred to as **chemotherapy + vitamin D2** is a therapeutic strategy being investigated in a Phase III clinical trial (NCT04523311) led by Jiuda Zhao for patients with breast cancer. This regimen combines standard adjuvant chemotherapy—which is customized based on clinical judgment and may include various cytotoxic agents—with supplemental vitamin D2 (ergocalciferol). The vitamin D2 is administered as a 10 mg injection before the start of treatment and every three weeks thereafter until the completion of the adjuvant chemotherapy course. The primary objective of this combination is to evaluate whether vitamin D supplementation can mitigate common chemotherapy-induced side effects, such as bone loss or neuropathy, thereby improving the quality of life and treatment tolerability for breast cancer patients.

Other names

Vitamin D2 supplementation during chemotherapyergocalciferol + chemotherapy