Drug intelligence / Profile preview

chenopodium formosanum extract

Development stage
Preclinical
Lead developer
TCI
Modality
Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules
Administration
Oral, Topical
01

Overview

Chenopodium formosanum extract is a natural botanical extract derived from the seeds, hull, or bran of *Chenopodium formosanum* (commonly called Djulis or Taiwanese quinoa), an endemic pseudocereal from Taiwan. The extract is rich in phenolic compounds, flavonoids (such as rutin and epicatechin), betalains (including betanin and betaxanthin), and phytoecdysteroids. Mechanistically, its primary actions include potent antioxidant activity (free radical scavenging and metal ion chelation), activation of endogenous antioxidant defense systems (notably the Nrf2/HO-1 pathway), anti-inflammatory activities (downregulation of IL-6 and TNF-α, inhibition of TLR4/NF-κB signaling), matrix preservation (downregulation of matrix metalloproteinases and prevention of collagen degradation), anti-glycation (reducing advanced glycation end products), and hepatoprotective effects. These properties give it potential applications in anti-aging skincare, liver protection, anti-diabetic, anti-obesity, anti-cancer, and functional foods[1][3].

Other names
chenopodium formosanum extractDjulis extractTaiwanese quinoa extractChenopodium fromosanum extract
02

Targets

NF-κBNFE2L2 (Nuclear factor (erythroid-derived 2)-like 2)TLR4 (Toll-like receptor 4)

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