chenpi extract

Chenpi extract is a preparation derived from the dried pericarp of Citrus reticulata (commonly known as tangerine or mandarin orange peel), widely used in Traditional Chinese Medicine (TCM). Its main bioactive constituents are **flavonoids** (such as nobiletin, naringenin, hesperetin, and polymethoxyflavones), **essential oils**, **pectin**, and **dietary fiber**. Chenpi extract exerts multiple pharmacological effects: - **Mechanism of action:** - Promotes the movement of spleen and stomach Qi, thus supporting digestion and alleviating gastrointestinal symptoms such as bloating, nausea, indigestion, and diarrhea[1][2][8]. - Modulates lipid and cholesterol homeostasis, showing anti-obesity and lipid-lowering properties[3][8]. - Shows anti-inflammatory, antioxidant, and immunoregulatory effects—activating antioxidant enzymes (superoxide dismutase, catalase), regulating cytokine and inflammatory mediator expression (e.g., lowering NF-κB, IL-1β, TNF-α), and protecting against oxidative stress[9]. - Improves respiratory inflammation, resolves phlegm, and relieves cough through essential oils and anti-inflammatory flavonoids[2][4][8]. - Demonstrates chemopreventive potential by activating the Nrf2-ARE antioxidant pathway and modulating genes and signaling pathways (PI3K-Akt, MAPK) related to cell proliferation and inflammation[6][7]. - Alters composition of the gut microbiota, increasing beneficial genera (Roseburia, Blautia, Subdoligranulum, Eubacterium) and affecting production of short-chain fatty acids[3][10]. - Candidate compounds within chenpi (such as hesperetin and nobiletin) target proteins AKT1, TP53, IL6, VEGFA, and MMP9, which are implicated in inflammation, cancer progression, and tissue protection[7]. - **Primary indications/uses:** - Traditionally: dyspepsia, bloating, nausea, poor appetite, cough with phlegm, chest congestion, fatigue[1][2][8]. - Investigated for respiratory diseases (COPD, chronic cough), metabolic disorders (obesity, hyperlipidemia, metabolic syndrome), liver protection, and chemoprevention (especially in the context of inflammation and cancer risk)[3][6][7]. - Used as a **dietary supplement** or functional food ingredient in teas, porridge, soups, and as herbal medicine[5]. - Not an approved pharmaceutical; primarily a traditional/dietary product.

Other names

chenpidried citrus peel extractaged citrus peel extractcitrus reticulata pericarp extractchen picitrus peel extract