Drug intelligence / Profile preview

chicory inulin-type fructan

Development stage
Unknown
Lead developer
Beneo
Modality
Recombinant Proteins and Enzymes, Small Molecules
Administration
Oral
01

Overview

**Chicory inulin-type fructan** is a natural, plant-derived dietary fiber primarily extracted from the root of *Cichorium intybus* (chicory). It is made up of linear fructose polymers (fructans) linked mainly by β-(2→1) bonds, which are resistant to human digestive enzymes, resulting in prebiotic activity within the gut. Mechanistically, chicory inulin-type fructan acts as a soluble fiber that increases stool bulk, modulates gut microbiota—stimulating beneficial species like *Bifidobacterium* and *Lactobacillus*—and reduces constipation symptoms[1][2][3]. Human studies further associate its intake with improvements in bowel movement frequency and consistency, potential antihyperglycemic effects (notably lowering HbA1c), modulation of lipid metabolism (adiponectin increase), and modest reductions in body weight, BMI, fat mass, and waist circumference[2][3]. Clinical use is as a **dietary supplement** for digestive health, weight management, and metabolic support.

Brand names
Orafti
Other names
chicory root inulininulin-type fructans from chicorychicory ITFchicory inulin

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