chikusetsusaponin V

**Chikusetsusaponin V** is a triterpenoid saponin extracted mainly from _Panax japonicus_ and related species, also known as ginsenoside Ro[7][15]. It demonstrates significant **anti-inflammatory** and **anti-obesity** effects in preclinical models. Mechanistically, chikusetsusaponin V inhibits the NF-κB pathway, reduces pro-inflammatory cytokines (TNF-α, IL-1β, IL-6), activates liver X receptor alpha (LXRα), and modulates SIRT1/NF-κB signaling[1][6][10][14]. Additionally, its anti-obesity efficacy is mediated by activation of the AMP-activated protein kinase (AMPK) pathway, resulting in downregulation of lipogenic and obesity-related genes and altered key metabolites in lipid metabolism[4][8]. Its biological activity has largely been investigated in cell and animal studies, with no evidence of pharmaceutical approval or formal clinical development.

Other names

chikusetsusaponin Vginsenoside Rochikusetsusaponin 5chikusetsusaponin5chikusetsusaponin-5