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Drug intelligence / Profile preview
China Medical Univ. xanthine oxidase compound 12r
- Development stage
- Unknown
- Lead developer
- China Medical University
01
Overview
China Medical Univ. xanthine oxidase compound 12r: sourced facts only. name: "The investigation provided some valuable SAR information and identified N-(3-(1H-imidazol-1-yl)-4-((2-methylbenzyl)oxy)phenyl)-1H-imidazole-4-carboxamide (12r, IC50 = 0.028 µM) as the most potent XO inhibitor with close in vitro potency to that of topiroxostat (IC50 = 0.017 µM)." [PMID:36801790]; target: "The investigation provided some valuable SAR information and identified N-(3-(1H-imidazol-1-yl)-4-((2-methylbenzyl)oxy)phenyl)-1H-imidazole-4-carboxamide (12r, IC50 = 0.028 µM) as the most potent XO inhibitor with close in vitro potency to that of topiroxostat (IC50 = 0.017 µM)." [PMID:36801790]; developer: "School of Pharmacy, China Medical University, 77, Puhe Road, North New Area, Shenyang 110122, China." [PMID:36801790]
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