China Pharma Univ. ERβ compound I11

China Pharma Univ. ERβ compound I11: sourced facts only. name: "Among 18 synthesized compounds, I11 exhibited potent SERT inhibition (IC50 = 16.92 ± 1.71 nM), strong ERβ agonism (EC50 = 3.66 ± 0.55 nM, approximately 6-fold selectivity over ERα), and favorable oral absorption and brain penetration." [PMID:42154662]; target: "Among 18 synthesized compounds, I11 exhibited potent SERT inhibition (IC50 = 16.92 ± 1.71 nM), strong ERβ agonism (EC50 = 3.66 ± 0.55 nM, approximately 6-fold selectivity over ERα), and favorable oral absorption and brain penetration." [PMID:42154662]; developer: "State Key Laboratory of Natural Medicines, Department of Natural Medicinal Chemistry, School of Traditional Chinese Pharmacy, China Pharmaceutical University, 639 Longmian Avenue, Nanjing 211198, China." [PMID:42154662]; stage: "Notably, I11 reduced immobility in forced swim and tail suspension tests in chronic unpredictable mild stress (CUMS) mice and improved social interaction while reducing inactivity in chronic social defeat stress (CSDS) models." [PMID:42154662]