Drug intelligence / Profile preview

China Pharma Univ. GPX4 compound 31

Development stage
Preclinical
Lead developer
China Pharmaceutical University
01

Overview

China Pharma Univ. GPX4 compound 31: sourced facts only. name: "Mechanism research showed that 31 promoted the degradation of GPX4, causing the accumulation of lipid ROS to induce ferroptosis." [PMID:37801824]; target: "Mechanism research showed that 31 promoted the degradation of GPX4, causing the accumulation of lipid ROS to induce ferroptosis." [PMID:37801824]; developer: "Jiangsu Key Laboratory of Bioactive Natural Product Research and State Key Laboratory of Natural Medicines, School of Traditional Chinese Pharmacy, China Pharmaceutical University, 24 Tong Jia Xiang, Nanjing, 210009, People's Republic of China." [PMID:37801824]; stage: "Animal experiments also proved that 31 could inhibit the growth of colon cancer cells in vivo and reduce the expression of GPX4 in tumor tissues." [PMID:37801824]

02

Targets

GPX4 (Glutathione peroxidase 4)

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