China Pharma Univ. PD-L1 compound I-5

China Pharma Univ. PD-L1 compound I-5: sourced facts only. name: "Collectively, these results suggest that compound I-5 is a promising small-molecule PD-1/PD-L1 inhibitor and warrants further in-depth investigation." [PMID:42151523]; target: "Collectively, these results suggest that compound I-5 is a promising small-molecule PD-1/PD-L1 inhibitor and warrants further in-depth investigation." [PMID:42151523]; developer: "Department of Medicinal Chemistry, China Pharmaceutical University, Nanjing, P. R. China." [PMID:42151523]; modality: "Collectively, these results suggest that compound I-5 is a promising small-molecule PD-1/PD-L1 inhibitor and warrants further in-depth investigation." [PMID:42151523]; stage: "At the cellular level, I-5 displayed low nonspecific cytotoxicity toward tumor cells, restored T-cell immune function by promoting interferon-γ (IFN-γ) secretion, and markedly enhanced peripheral blood mononuclear cell (PBMC)-mediated cytotoxicity against MDA-MB-231 tumor cells." [PMID:42151523]