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China Pharma Univ. PKM2 compound 29e
- Development stage
- Preclinical
- Lead developer
- China Pharmaceutical University
01
Overview
China Pharma Univ. PKM2 compound 29e: sourced facts only. name: "an excellent derivate 29e showed good activity on PKM2 (AC50 = 86.29 nM) and displayed significant antiproliferative activity against HT29 (IC50 = 0.66 μM) and SW480 (IC50 = 0.22 μM) cells." [PMID:34847663]; target: "an excellent derivate 29e showed good activity on PKM2 (AC50 = 86.29 nM) and displayed significant antiproliferative activity against HT29 (IC50 = 0.66 μM) and SW480 (IC50 = 0.22 μM) cells." [PMID:34847663]; developer: "Jiangsu Key Laboratory of Bioactive Natural Product Research and State Key Laboratory of Natural Medicines, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing 210009, People's Republic of China." [PMID:34847663]; stage: "Furthermore, 29e significantly suppressed tumor growth in the HT29 xenograft model without obvious toxicity." [PMID:34847663]
02
Targets
PKM2 (Pyruvate kinase M2 isoform)
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